Among the issues for discussion: Israel's 21-month war against Hamas in Gaza and questions over how hard Trump will push for an end to the conflict.
Trump has made clear that following the 12-day war between Israel and Iran, he would like to see the Gaza conflict end soon.
The meeting between Trump and Netanyahu could give new urgency to a U.S. ceasefire proposal being discussed by Israel and Hamas, but whether it leads to a deal that ends the war is unclear.