The targets are primarily U.N.-related groups that focus on climate, labor and other issues that the Trump administration has criticized for catering to "woke" initiatives.
The decision to withdraw comes as ongoing U.S. military efforts and threats have rattled allies and adversaries alike, including the capture of Venezuelan leader Nicolás Maduro and indications of U.S. intention to take over Greenland.
On Wednesday morning, the Trump administration seized two Venezuela-linked sanctioned petroleum tankers, in its latest move to establish control over the world's largest proven reserves of crude oil.